Some would say our love/hate relationship with carbohydrates has gotten a little out of hand and made eating a lot more complicated than it needs to be. It’s easy to see where our confusion originates. Carbs, after all, provide us with our body’s primary source of energy after they are broken down into glucose or blood sugar. On the flip side, carbohydrates drive up insulin, causing our bodies to hold onto fat. The best way to get a grip on this carb conundrum may be to recognize and avoid the worst kind of carbs for your body (the highly processed, sugary, refined carbs) and figure out the best and worst times to eat carbs for your health and lifestyle.

We asked nutritionists and other experts for help. Here’s how they identified the worst times to eat carbs, and for even more healthy tips, be sure to check out our list of 15 Underrated Weight Loss Tips That Actually Work.

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The worst times to eat carbs will vary from person to person, so you have to evaluate your body and your lifestyle, says certified nutritionist Reda Elmardi, CEO of StrongChap.com. If you don’t exercise and also have a sedentary job, don’t eat high carb meals for breakfast, lunch and dinner; cut carbs from one or two of those meals, he says.

“If you are very active consistently throughout the day then anytime is fine to have carbs—just don’t overdo the calories,” says Elmardi.

The physical therapist and bodybuilder advises people who are mostly sedentary but have a set workout time of day to plan to consume most of the day’s carbohydrates around that workout.

“But it’s not essential,” he says. “The body can store glycogen for use at a later time; as long as you use the energy at some point you will be fine.”

Here are 8 Side Effects of Eating Too Many Carbs.

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Don’t bash carbs; we need them to power through our workday, school day, and workouts, says National Academy of Sports Medicine certified trainer and nutrition consultant Natasha Funderburk, RN, BSN.

“When we can learn to view carbohydrates as our main energy source, it becomes easier to understand the timing of when it’s best to eat them or avoid them,” says Funderburk.

The worst time to eat carbohydrates is when you no longer need the energy. For most of us, that’s in the evening when you’re sitting on the couch. “When we carb load to sit in front of the TV, our metabolism is already powering down, and our body is going to end up storing those carbs as fat since it has no use to burn through as fuel.”

For some inspiration to get off that couch, read Ugly Side Effects of Not Working Out, According to Science.

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Make a habit of limiting carbohydrates two to three hours before you go to bed, advises Morgyn Clair, RD, a registered dietitian nutritionist with SprintKitchen.com. “Keep nighttime snacks to 15 grams of carbs or less,” she says.

“[Because] carb’s main role in the body is energy and the body won’t be using energy during rest, the carbs are generally stored as fat,” says Clair.

Certified Nutrition Specialist Dr. Josh Axe, DC, founder of Ancient Nutrition broadens that advice to include eating any food 2 to 3 hours before bed to support digestion, metabolic health, and improved sleep.

“When you avoid eating carbs too close to bedtime, you’re giving your body a chance to digest and you’re also fasting overnight, which can benefit for your blood sugar and insulin sensitivity,” he says. “If possible, aim to go 12 hours overnight (between dinner and breakfast the next morning) without eating anything, including carbs.”

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You may have heard about a counter-intuitive form of carbohydrate timing called “carb backloading” for weight loss. The idea behind this trendy diet is to significantly reduce carbohydrates that you eat early in the day, at breakfast and lunch, and consume the majority of carbs later in the day (for dinner), explains nutritionist Lisa Richards, author of The Candida Diet.

“It is thought that this optimizes the body’s natural insulin sensitivity making weight loss more efficient,” she says.

And by loading up on carbs in the hours after exercising later in the day, those carbohydrates will be better absorbed by your muscles.

Also, loading up on carbs in the evening and avoiding carbs at the morning meal after a nighttime of fasting while you sleep, in theory, you force your body to turn toward stored fat for fuel during the daytime hours when you are active. It’s a similar concept to intermittent fasting and the keto diet.

No matter what type of carb timing you follow, the key is “focusing on complex carbs,” says Richards. “Reducing or eliminating refined carbohydrates from the diet is a wise decision for your overall health, not just weight loss or performance. Refined carbohydrates are inflammatory and can lead to poor gut health and candida overgrowth, among other issues.”

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“If you’re prediabetic or diabetic, you’ll likely need to be more careful about your carb consumption,” says Axe. You may need to limit the number of grains and fruits you consume, and you’ll want to avoid processed carbs and added sugar, plus sugary drinks. “Another circumstance to consider cutting carbs is if you’re looking to lose weight. You might opt to try a low carb diet such as the keto diet (a high-fat diet that’s very low in carbs) which can help promote fat loss,” he says.

Here are Easy Ways You Can Prevent Heart Disease and Diabetes, According to a Registered Dietitian.

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For many of us, our bodies never have a chance to burn the energy we’ve already stored because we never let our fuel tanks run low and we’re eating carbs throughout the day and constantly triggering insulin spikes.

“A person has spiked it again with their mid-morning snack, and then lunch, and afternoon snack; essentially a person is living a life in which every waking moment is spent in a state of elevated insulin,” says metabolism research scientist at Brigham Young University Benjamin Bikman, Ph.D., author of Why We Get Sick.

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When you are inactive, your body is in a low state of physical fitness or you have high levels of body fat, it’s not a good time to consume carbohydrates.

“The body can better handle carbohydrates during and after physical activity, as well as when levels of fitness are high and body fat levels are lower, that is 15% or less for men and 20% or less for women,” says Ryan Andrews, RD, CSCS, a principal nutritionist for Precision Nutrition.

Beyond the three-hour window after exercising, you should eat mostly protein and fat and fewer carb-dense foods. “If you plan a higher carbohydrate intake at times when your body is better equipped to handle it, insulin will be under your control, and the body will function better,” Andrews says.

Rather than worry about when you should or shouldn’t consume carbohydrates, focus on choosing the right kinds of carbohydrates, stress nutritionists. Anytime can be the worst time to eat carbs if those carbs happen to be the sugary, highly processed kind. “Aim to eat unprocessed carbs that are high in fiber no matter what time of day you’re eating carbs,” says Dr. Axe. Examples of healthy carbs include vegetables, whole pieces of fruit (rather than juice), whole grains like oats or quinoa, sweet potatoes, and other potatoes, plus beans and legumes. (Related: The Surprising Side Effects of Eating Oatmeal, According to Science.) Dairy, nuts, and seeds also provide you with some carbs (choose unsweetened dairy to avoid too much sugar).

prune health benefits
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Chewy and sweet, prunes are essentially plums that have been dehydrated for preservation. They can last in your pantry for about six months and provide a ton of versatility in practically any meal. Plus, they are little nutritious powerhouses. “Prunes have many different health benefits, from gastrointestinal health to bone preservation, modulating immune response, diabetes and atherosclerosis and satiety,” says Shirin Hooshmand, Ph.D., Professor of Nutrition at San Diego State University.

Although this yummy dried fruit offers up some serious health benefits, make sure to pay attention to ingredient lists and purchase varieties that solely list prunes as the only ingredient (try to avoid options with any added sugars or oils). Here’s everything you need to know about prunes and why they are worthy of a spot in your grocery cart.

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Prune Nutrition Stats

Serving Size: 4 Prunes (38g)

  • 90 calories
  • 0g total fat
  • 0g saturated fat
  • 0mg cholesterol
  • 0mg sodium
  • 24g total carbohydrate
  • 3g dietary fiber
  • 14g total sugars
  • 0g added sugars
  • 1g protein
  • 20mg calcium (2% DV)
  • 0.4mg iron (2% DV)
  • 280mg potassium (6% DV)
  • 23mcg Vitamin K (20% DV)
  • 0.1mg riboflavin (8% DV)
  • 0.9mg niacin (6% DV)
  • 0.1mg Vitamin B6 (6% DV)
  • 0.2mg pantothenic acid (4% DV)
  • 15mg magnesium (4% DV)
  • 0.1mg copper (10% DV)
  • 0.1mg manganese (4% DV)

    Prune health benefits:

    prunes on a vintage brass spoon

    Westend61Getty Images

    Prune superpowers go far beyond the bathroom! Here are some reasons to start incorporating prunes into your diet:

    • Can support bone health: Dr. Hooshmand has been conducting research in the area of bone health and prunes for the past 15 years. In a recent clinical trial conducted, Dr. Hooshmand and her team found that osteopenic postmenopausal women who ate 5-6 prunes per day (one serving of prunes) for six months was effective in preventing bone loss. “Previous research also found that eating 10-12 prunes per day for one year was associated with increased bone mineral density and improved indicators of bone turnover in postmenopausal women,” she says. Additionally, Dr. Hooshmand shares that interesting new animal research suggests that prunes may help prevent bone loss in people exposed to radiation, such as astronauts in space.
    • May promote heart health: A serving of prunes meets 11% of the daily value for fiber, which plays a role in lowering blood cholesterol. Initial research from the University of California, Davis found that men with moderately elevated cholesterol were able to reduce both total and “bad” LDL cholesterol after eating about 12 prunes daily.
    • Support healthy digestion: The fiber content of prunes may be to thank for their laxative effect, but scientists point to the combination of fiber, phenolic compounds and sorbitol within prunes that are likely what does the trick. Research supports that prunes can significantly increase stool weight and frequency, making them a great natural alternative to promote healthy bowel function.
    • May have anti-inflammatory properties: Since prunes are rich in polyphenols, these antioxidants can help decrease inflammation and protect against DNA damage. Compared to fresh plums, prunes dried at 60 and 85°C may actually have a higher antioxidant activity.

      And what about prune juice?

      Unlike other fruit juices, most popular brands of prune juice do actually contain a good source of fiber per serving. Warm prune juice itself has been long used as a natural constipation remedy as well. “In my opinion, probably consuming prune juice could be effective in terms of bone health to some degree, but we only have data from clinical trials testing effects of whole prunes on bone health,” says Dr. Hooshmand.

      How many prunes should I eat per day?

      Dr. Hooshmand says how many prunes you should eat in a day depends on the size of the prunes themselves, but current research recommends 50 grams of prunes per day which is equal to about 5 to 6 prunes. If you’re not used to eating prunes or other fiber-rich foods, start slow with 1 to 2 prunes per day and gradually work your way up. “For people who have a low intake of fiber in their diet, in general we recommend introducing prunes gradually, avoid consumption of prunes on an empty stomach and spread the intake throughout the day,” says Dr. Hooshmand.

      How to add prunes to your diet:

      “There are plenty of different ways to enjoy the prune as part of your diet: from smoothies to salads and soups to savory dinner dishes. Prunes can even be used as a sugar and fat substitute in baked goods,” Dr. Hooshmand shares.

      Enjoy this yummy dried fruit by itself or try it in a variety of different ways:

      • Use prunes alongside your favorite variety of nuts in a healthy homemade trail mix
      • Add chopped prunes as a topping to oatmeal or yogurt
      • Incorporate prunes in stews or tagine for a sweet savory twist
      • Add a prune or two to your morning smoothie
      • Toss chopped prunes into salad alongside your favorite veggies and vinaigrette
      • Use prunes for natural sweetness and fiber in energy bites
        Registered Dietitian
        Stefani Sassos is a Registered Dietitian Nutritionist with a Bachelor of Science degree in Nutritional Sciences from The Pennsylvania State University and a Master of Science degree in Clinical Nutrition from New York University.

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        If losing weight is one of your 2021 goals, you may want to consider a low-fat vegan diet. A new study published on Feb. 5 by the Physicians Committee for Responsible Medicine in the Journal of the American College of Nutrition showed that eating a low-fat vegan diet was actually more effective for weight loss than the Mediterranean diet, which is typically ranked the best diet for weight loss. Are you surprised?

        The two diets were compared in a 36-week trial. For 16 weeks, half of the participants were randomly assigned to a low-fat vegan diet, eating vegetables, fruits, whole grains, and legumes, while limiting plant fats like oil, avocado, nuts, seeds, and coconut. The other half followed the Mediterranean diet, which is also full of veggies, fruits, and whole grains, but includes olive oil and a moderate amount of fish and chicken. Neither group had calorie restrictions.

        After the 16 weeks, the participants returned to their original diets for four weeks, then followed the opposite diet for another 16 weeks.

        The study showed that eating a low-fat vegan diet had better results for weight loss, cholesterol levels, and improved body composition and insulin sensitivity. Participants following the Mediterranean diet lost no weight, but those following a low-fat vegan diet lost an average of 13.2 pounds, including an average of 7.5 pounds of fat.

        While many experts think of the Mediterranean diet as one of the best ways to lose weight, the study’s author, Neal Barnard, MD, president of the Physicians Committee, said the diet’s inclusion of fatty fish, dairy products, and oils seems to be the reason none of the participants lost weight on it.

        I reached out to registered dietitian Susan Macfarlane, MScA, to get her opinion on this study and she explained to POPSUGAR, “In this study, the weight loss can be attributed to a calorie reduction.” The participants eating the low-fat vegan diet reported that they were naturally eating 500 fewer calories, but that their calorie intake didn’t change while eating the Mediterranean diet.

        Eating veggies, fruits, whole grains, and legumes that are naturally lower in calories than foods that contain fat allowed the participants to reduce their calorie intake without reducing the volume of food they were eating, Macfarlane said. These types of foods also have a high water and fiber content, which enhances their satiety, she added, so you feel full eating fewer calories. Eating a low-fat vegan diet means you’re also not eating high-calorie processed foods, Macfarlane said, which are easy to overeat, leading to weight gain.

        Related:

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        To add my personal take, I started following a low-fat, high-carb vegan diet in July 2020. I was already not eating meat or dairy, but was eating eggs, oil, avocado, coconut, and tons of seeds, and nuts and nut butters. Switching to a low-fat vegan diet offered me so many benefits. As long as I was eating enough carbs from starches, not consuming sugar or processed foods or flours, I had more energy for my workouts, got leaner, and once I got used to all the fiber I was eating from beans and non-starchy veggies, my digestion had significantly improved.

        It’s important to emphasize that this study is referring to a low-fat vegan diet, which means your diet is 10 to 15 percent fats – not zero fat. Registered dietitian Whitney English Tabaie, MS, warned that consuming zero fats could backfire, since fats offer a feeling of satiety. She said in a previous interview, “Someone could end up overeating later to make up for their low-fat meals,” which would then lead to weight gain. Registered dietitian Sarah Rueven, MS, CDN from Rooted Wellness added that not eating enough fat could lead to nutrient deficiencies from not getting enough fat-soluble vitamins (A, D, E, and K).

        The bottom line is eating a more whole, plant-based diet is a healthy way to eat, since it encourages a person to eat vitamin- and fiber-rich fruits, veggies, and whole grains. But Tabaie said that “eating a balanced diet with moderate amounts of protein, fat, and complex carbohydrates at each meals” is essential for optimal health. For a general macro breakdown for meals, registered dietitian Leslie Langevin, MS, author of The Anti-Inflammatory Kitchen Cookbook recommends dividing your plate into half plate low-carb veggies, one-quarter plate protein, and one-quarter plate carbs plus fat.

        DRESDEN, Germany — “An apple a day keeps the doctor away,” especially when to comes to fighting off dementia. An international study finds the famously healthy fruit is rich in chemicals that fuel neurons, improving learning and memory.

        Experiments on mice discovered grey matter increased after they were injected with phytonutrients, like flavonoids, which are abundant in fruits and vegetables. The effects were similar to those seen after exercise, which can also boost brain function.

        Corresponding author Professor Gerd Kempermann from the German Center for Neurodegenerative Diseases says these dietary compounds are “vital for maintaining cognitive function.”

        “They can have positive effects on different parts of the body – including the brain,” Kempermann says in a statement to SWNS.

        How do these substances boost the brain?

        These antioxidants dampen inflammation and strengthen the immune system. Researchers took stem cells from the brains of lab rodents and cultured them in petri dishes. After adding apple extracts like quercetin or DHBA (dihydroxybezoic acid), more neurons grew and fewer died.

        Hippocampal precursor cells
        Hippocampal precursor cells differentiate into neurons when treated with the apple-derived compound DHBA. (Credit: German Centre for Neurodegenerative Diseases)

        “High concentrations of phytonutrients from apples stimulate the generation of new neurons – a process called neurogenesis,” Kempermann explains.

        The results, published in Stem Cell Reports, were then confirmed in trials involving actual mice. Stem cells multiplied and produced more neurons after the scientists added in high doses of quercetin or DHBA.

        Specifically, this applied to distinct structures in the adult brain including the hippocampus, vital for memory, learning, and navigation.

        Apples contain pro-neurogenic compounds in both their peel and their flesh,” study authors write in their report.

        Quercetin resides in the apple’s peel. The pigment adds color to the fruit and belongs to the flavonoid family. DHBA is a natural preservative unrelated to flavonoids. It is responsible for giving fruit its distinctive aroma. Both chemicals act in similar ways however, protecting cells by destroying harmful free radicals.

        “‘An apple a day keeps the doctor away.’ There may be some truth to this aphorism,” researchers write. “Apart from being a source of energy, food is known to influence an individual’s overall fitness. A growing number of studies have demonstrated the health benefits of phytochemicals, the chemical substances found in plants.”

        Finding ways to stop disease in our food?

        apples antioxidants
        (Credit: Apple Peel and Flesh Contain Pro-neurogenic Compounds – Stem Cell Reports)

        These substances include resveratrol in red grapes and EGCG (epigallo-catechin-3-gallate) in green tea. Previous studies find they have a link to reducing the risk of diseases like cancer, heart disease, and dementia. Researchers believe quercetin and DHBA act in combination to promote neurogenesis and brain function when consumed in high amounts.

        “The effects were comparable to those seen after physical exercise – a known stimulus for neurogenesis,” Kempermann tells SWNS.

        When the mice received apple juice however, study authors say there was no benefit to brain health as it contains smaller quantities of the beneficial ingredients. The findings could have implications for protecting against Alzheimer’s disease. With no cure in sight for the degenerative condition, there is an increased focus on lifestyle factors that can help stop or delay its onset.

        “As mammals evolved with exposure to particular diets, naturally abundant compounds may have become part of the set of environmental co-determinants that shaped brain structure and function,” study authors write.

        “Future studies will be required to determine if these and other phytonutrients can enhance learning and cognitive function in animal models – and in humans,” Kempermann adds.

        SWNS writer Mark Waghorn contributed to this report.

        A drug that suppresses appetite has been described as “gamechanger” in the fight against obesity after research showed it could cut body weight by up to 20%.

        The study into the effects of semaglutide on obesity by a University College London (UCL) team found that more than one third (35%) of people who took it lost more than one-fifth of their total body weight.

        Researchers say it means that for the first time it is possible to achieve through drugs what was previously only possible through weight-loss surgery.

        The negative health implications of obesity have been brought into even sharper focus by the COVID-19 crisis because of its effect on mortality rates.

        Semaglutide works by hijacking the body’s own appetite regulating system in the brain, leading to reduced hunger and calorie intake.

        The UCL randomised control trial involved 1,961 adults who were either overweight or obese (average weight 105kg/16.5 stone, body mass index 38kg/m2), and took place at 129 sites in 16 countries across Asia, Europe, North America, and South America.

        Participants took a 2.4mg dose of semaglutide or matching placebo weekly via an injection under the skin.

        Overall, 94.3% of participants completed the 68-week study, which started in autumn 2018.

        Those taking part also received individual face-to-face or phone counselling sessions from registered dietitians every four weeks to help them adhere to the reduced-calorie diet and increased physical activity, providing guidance, behavioural strategies and motivation.

        In those taking semaglutide, the average weight loss was 15.3kg, with a reduction in BMI of 5.54.

        The placebo group observed an average weight loss of 2.6kg (0.4 stone) with a reduction in BMI of 0.92.

        Publishing the data in the New England Journal for Medicine, lead author, Professor Rachel Batterham from UCL’s Centre for Obesity Research, said: “The findings of this study represent a major breakthrough for improving the health of people with obesity.

        “Three quarters (75%) of people who received semaglutide 2.4mg lost more than 10% of their body weight and more than one-third lost more than 20%.

        “No other drug has come close to producing this level of weight loss – this really is a gamechanger.

        “For the first time, people can achieve through drugs what was only possible through weight-loss surgery.”

        Professor Batterham added that the drug could have major implications for UK health policy for years to come.

        Along with the weight loss, the group taking semaglutide saw reductions in risk factors for heart disease and diabetes, such as waist circumference, blood fats, blood sugar and blood pressure, and reported improvements in their overall quality of life.

        Semaglutide is already clinically approved for use by patients with type 2 diabetes, though at lower doses than used in the obesity trial.

        Evidence from the study has been submitted for regulatory approval as a treatment for obesity to the National Institute of Clinical Excellence (NICE), the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA).

        Boiled, fried, scrambled or in an omelette, whole eggs pose a threat to health and eating more of them increases your risk of death, a study claims. 

        Researchers found eating just half a whole egg — which includes the yolk and the white — increases the likelihood of dying by seven per cent.

        Risk of death increases by a further seven per cent for every half an egg on top of this, so a person eating one egg a day has at 14 per cent greater chance of death than someone who avoids the food. 

        Chinese researchers who led the study believe high fat and cholesterol levels in eggs are to blame. 

        They warned that people should use only the whites or switch to healthier egg substitutes, which lower the risk of dying. 

        Substituting an equivalent amount of nuts or legumes for half a whole egg reduced death rates by up to a third. Poultry, dish or dairy products had a similar effect.

        Scroll down for video  

        Boiled, fried, scrambled or in an omelette, whole eggs pose a threat to health and eating more of them increases your risk of death, a study warns (stock)

        Boiled, fried, scrambled or in an omelette, whole eggs pose a threat to health and eating more of them increases your risk of death, a study warns (stock)

        Boiled, fried, scrambled or in an omelette, whole eggs pose a threat to health and eating more of them increases your risk of death, a study warns (stock)

        WHAT IS HIGH CHOLESTEROL?

        Cholesterol is a fatty substance that is vital for the normal functioning of the body.

        But too much can cause it to build up in the arteries, restricting blood flow to the heart, brain and rest of the body.

        This raises the risk of angina, heart attacks, stroke and blood clots. 

        Cholesterol is made in the liver and is carried in the blood by proteins.

        The first – high-density lipoprotein (HDL) – carries cholesterol from cells to the liver where it is broken down or passed as waste. This is ‘good cholesterol’.

        ‘Bad cholesterol’ – low-density lipoprotein (LDL) – carries cholesterol to cells, with excessive amounts then building in the artery walls.

        High cholesterol can be genetic but it is also linked to a diet rich in saturated fat, as well as smoking, diabetes, high blood pressure and a family history of stroke or heart disease. 

        Blood cholesterol is measured in units called millimoles per litre of blood, often shortened to mmol/L.

        A healthy adult’s overall level should be 5mmol/L or less, while their LDL level should be no more than 3mmol/L. An ideal level of HDL is above 1mmol/L.

        Cholesterol can be lowered by eating a healthy, low-fat diet; not smoking; and exercising regularly.

        If these do not help, cholesterol-lowering medication like statins may be prescribed.

        Source: NHS  

        Researchers gave a questionnaire to more than half a million Americans  between 1995 and 1996 and followed them for 16 years. 

        Data from this study, published in PLOS ONE, shows 129,328 people who filled out the original form died. 

        Co-author Professor Yu Zhang, of Zhejiang University said: ‘In this study, intakes of eggs and cholesterol were associated with higher all cause, cardiovascular disease and cancer mortality.’ 

        Professor Zhang said: ‘The increased mortality associated with egg consumption was largely influenced by cholesterol intake.’

        The link between eggs and health has been debated for years. They have long been thought of as a healthy dietary addition.

        They are included in many country’s national dietary guidelines. But the food, specifically the yolk, is high in cholesterol – which is known to be harmful.

        Researchers asked the participants about how much cholesterol they had as part of their diet on top of eggs and found an additional 300 milligrams of cholesterol a day were 19 per cent more likely to die over the next 16 years.

        Deaths specifically from cancer and cardiovascular disease rose by 24 and 16 per cent, respectively.

        There is no cholesterol in the white of a medium-large chicken egg, and around 186 mg in the yolk.

        ‘Our findings suggest limiting cholesterol intake and replacing whole eggs with egg whites/substitutes or other alternative protein sources for facilitating cardiovascular health and long-term survival,’ the authors say.  

        Cholesterol can build up in the arteries leading to a blood clot which can cut off blood supply, potentially triggering strokes or heart disease. 

        The NHS says eggs are a good choice as part of a healthy, balanced diet. As well as being a source of protein, they also contain vitamins and minerals.

        It says there is no recommended limit on how many eggs people should eat, but advises cooking them without adding salt or fat. Frying can increase their fat content by around 50 per cent.

        Researchers found eating just half a whole egg — which includes the yolk and the white — are seven per cent more likely to die. Likelihood of death increases by a further seven per cent for every half an egg on top of this, so a person eating one egg a day is at 14 per cent higher risk of death than someone who avoids the food

        Researchers found eating just half a whole egg — which includes the yolk and the white — are seven per cent more likely to die. Likelihood of death increases by a further seven per cent for every half an egg on top of this, so a person eating one egg a day is at 14 per cent higher risk of death than someone who avoids the food

        Researchers found eating just half a whole egg — which includes the yolk and the white — are seven per cent more likely to die. Likelihood of death increases by a further seven per cent for every half an egg on top of this, so a person eating one egg a day is at 14 per cent higher risk of death than someone who avoids the food

        ‘This research makes it possible to look at relationships between what people ate in the past and whether that could be related to disease or death in the future,’ says Dr Ada Garcia, a senior lecturer in Public Health Nutrition at the University of Glasgow who was not involved in the research, saus. 

        ‘The authors took a very careful approach to analysed the data and consider many aspects that could distort the findings.

        ‘The study concluded that retired people who ate more whole eggs seven per cent higher risk to develop cardiovascular disease. The highest consumption of eggs was about half a small egg in 2000 Kcal per day.’

        However, she criticises the methodology and conclusions of the Chinese team, saying: ‘Being overweight or obese, smoking or consuming too much alcohol and not being physically active are much more important factors to consider for prevention of chronic diseases and related death.

        ‘The conclusions of this study are overblown. Blaming eggs alone for an increased risk of cardiovascular disease is a simplistic and reductionist approach to the concept of diet and disease prevention.’   

        After 40 years of effort, researchers have finally succeeded in switching off one of the most common cancer-causing genetic mutations in the human body. The finding promises to improve treatment for thousands of patients with lung and colorectal cancer, and may point the way to a new generation of drugs for cancers that resist treatment.

        The finding has already led to a new medication, sotorasib, by the drugmaker Amgen. Other companies are close behind with their own versions.

        Amgen tested its drug in patients with the most common type of lung cancer, called non-small cell cancer. The disease is diagnosed in 228,000 Americans a year, and for most patients in the advanced stages, there is no cure.

        The new drug attacks a cancer-causing mutation, known as KRAS G12C, that occurs in 13 percent of these patients, almost all of whom are current or former smokers. Sotorasib made the cancers shrink significantly in patients with the mutation, Amgen reported last week at the World Conference on Lung Cancer.

        On average, tumors in the patients stopped growing for seven months. In three out of 126 patients, the drug seems to have made the cancer disappear entirely, at least so far, although side effects included diarrhea, nausea and fatigue.

        It already is routine to test lung cancer patients for the mutation, because they are often resistant to other drugs, said Dr. John Minna, a lung cancer specialist at the University of Texas Southwestern Medical Center in Dallas.

        Amgen’s drug is not as drastically effective as some new cancer medicines, said Dr. Bruce Johnson, the chief clinical research officer at the Dana-Farber Cancer Institute in Boston. But in combination with other drugs, those targeting specific mutations can change the course of the disease in many patients, he added.

        For example, drugs targeting specific mutations in melanoma patients at first seemed unimpressive, but when combined with other medicines, they eventually changed prospects for patients with this deadly disease.

        “The more I looked at it, the more optimistic I became,” Dr. Johnson said of Amgen’s new data.

        While the KRAS G12C mutation is most common in lung cancer, it also occurs in other cancers, especially in colorectal cancer, where it is found in up to 3 percent of tumors, and particularly in pancreatic cancer. KRAS mutations of some type are present in 90 percent of pancreatic tumors.

        How the off-switch was discovered is a story of serendipity and persistence by an academic chemist who managed the seemingly impossible.

        In 2008, that chemist, Kevan Shokat, a professor at the University of California, San Francisco, decided to focus on the mutated gene. It had been discovered 30 years earlier in rats with sarcomas, a type of cancer that begins in bones and soft tissues.

        Researchers found the mutation in human tumor cells, and then discovered that it was one of the most frequently mutated genes in cancers of many types. Different cancers tend to spring from different mutations in the KRAS gene and the protein it encodes. The G12C mutation occurs mostly in lung cancers.

        The search for drugs to block previously discovered cancer-causing mutations was always straightforward: Researchers had to find a molecule that attached to the mutated protein and could stop it from functioning. That strategy worked for so-called kinase inhibitors, which also block a protein created by gene mutations. There are 50 approved kinase inhibitors on the market now.

        KRAS was different. The gene directs production of a protein that normally flexes and relaxes thousands of times a second, as if it is panting. In one position, the protein signals cells to grow; in the other, it stops the growth. With the KRAS mutation, the protein remains mostly in an “on” position, and cells are constantly forced to grow.

        The standard solution would be a drug that would hold the mutated protein in the “off” position. But that seemed impossible. The protein is large and globular, and it doesn’t have deep pockets or clefts on its surface where a drug could slip in. It was like trying to drive a wedge into a ball of solid ice.

        “Our medicinal chemists referred to it as the Death Star,” said Dr. David Reese, executive vice president for research and development at Amgen. “It was so smooth.”

        So Dr. Shokat and his colleagues began looking for a molecule that could do the trick. Five years later, after screening 500 molecules, they found one and discovered why it worked.

        Their drug held the protein steady, making a crevice visible on its surface. “We never saw that pocket before,” Dr. Shokat said. The protein normally flexes and relaxes so quickly that the narrow groove had almost been impossible to see.

        There was more good news. The drug attached itself to cysteine, an amino acid that occurs in the groove only because of the KRAS mutation. The drug worked only against the mutated protein, and therefore only against cancer cells.

        “It is really specific,” Dr. Shokat said. “That’s what’s amazing.” He published his findings in 2013, causing a sensation in the field.

        Dr. Reese, of Amgen, said that the data “gave us the proof that we could actually do this,” and that “it silenced many of the doubters.”

        Dr. Shokat, too, began working on a drug, which is now being developed by Johnson and Johnson. At least eight companies have their own KRAS inhibitors in clinical trials.

        Lung cancer is only the beginning, Dr. Shokat said. The next challenge is pancreatic cancer, one of the most lethal types: “KRAS is the signature mutation for pancreatic cancer,” he added.

        Most patients have such a mutation, and while it makes the disease very difficult to treat, now it may also make the cancer particularly vulnerable. Researchers have already found drugs that seem promising.

        Intimate Health and Obesity, How Obesity Can Sabotage a Healthy Manhood. 

         

         

         

         

        Intimate Health and Obesity.

        By Man Health

         

        When talking about obesity, experts and armchair experts alike focus on the major diseases brought on by obesity and the surface issues of beauty and belonging.

        There’s a lot of discussion and information out there about diabetes, heart disease, and other issues related to obesity.

        But what about intimate health? Shouldn’t that conversation be happening, too? We think so. So, let’s talk about obesity, intimate health, and what people need to know.

         

         

        Intimate Health and Obesity: What Are the Risk Factors?

         

        Many men suffering from obesity may also find themselves dealing with a diagnosed medical male organ dysfunction or a psychological issue with having intimate relations.

        That’s not to say that all obese men have these problems; however, obesity certainly raises their risk.

         

         

        Relations Stoppers: Medical.

         

        Men who have diseases such as high cholesterol, hypertension, heart disease, stroke, and diabetes often experience issues with intimate health.

        In fact, men who have diabetes are 50 percent more likely to have member dysfunction (MD) than other men.

        Obesity contributes to excess narrowing and hardening of the blood flow. Which makes it more difficult to swirl around a larger body and down to the member in the vigor that causes the hardness.

        These diseases all contribute in some way to the prevention of either getting hard or maintaining the firmness.

        They damage the inner linings of the blood vessels of the member, which then causes a restriction in blood flow due to lack of dilation.

        Obesity can also happen as the result of, and reduce, the amount of androgen in the body (it’s the original double-edged sword here).

        Androgen starts taking a dip in men between ages 40 and 50. Androgen starts the whole hardness problem off and without it, or with less of it, drive diminishes.

        Finally, the inevitable cause: age. With age, stamina decreases. The entire body ages, so it’s natural that a man who was used to getting hard four times in one day in his 20s may only have the urge or ability three times a week in his 60s.

         

         

        Relations Stoppers: Psychological.

         

        Often overlooked, psychological reasons can cause huge waves in a man’s intimate health. Of course, issues such as depression and anxiety can physically manifest as MD. However, there are much more nefarious effects than MD.

        An obese man may be able to produce and maintain hardness without trouble, but that doesn’t necessarily mean he isn’t having problems.

        Poor self-image is another reason an obese man may shy away from intimacy with a partner. Potential rejection, fear of another person’s unkind judgment; or a demoralizing sense of self can also lead an obese man to ignore his intimate health.

         

         

        An Easy Reversal.

         

        Thankfully, research has shown that 95 percent of male organ dysfunction can be easily treated. First and foremost, a man must address the root cause of his problem, be that medical or mental.

        After that, he needs to take doctor recommendations and make lifestyle changes.

        Things such as adopting a healthy diet, bringing more movement into each day; getting adequate sleep, and not smoking are all critical parts of reversing intimate dysfunction.

        Doctors also say that a weight reduction of as little as ten percent within a two-month period will vastly improve the issue.

        Mental health interventions such as therapy and medication may also be part of a treatment plan.

        While making these changes, give the member a little extra care. Use an expressly formulated male organ health crème. (Health professionals recommend Man 1 Man Oil, which has been clinically proven safe and mild for skin) to strengthen and protect the member.

        Look for creams that list L-carnitine as an ingredient, as it is a science-backed guardian against peripheral nerve damage.

        Find a crème with vitamins A and C to ward off bacteria that can result from sweating, and to boost collagen production while fighting against agents of early aging.

         

         

          

        Image result for Intimate Health and Obesity.

         

         

        How Obesity Can Sabotage a Healthy Manhood.

        By Man Health

         

        Obesity is quickly becoming a serious public health crisis. But while many people know that obesity can lead to certain problems. Such as diabetes and heart disease, many aren’t aware of some of the other, more hidden dangers of being overweight.

        While many men who are carrying extra pounds still have a quite satisfying sensual life and run into no problems with member care. There are also those who have encountered more than a few male organ problems.

        Here’s what a man needs to know about maintaining healthy manhood in the face of obesity.

         

         

        Ways obesity can affect member health.

         

        Though it’s obvious by now that obesity affects several body functions, including the heart, just how does it affect a man’s time in the sack? Here’s how.

         

        1) He doesn’t have as much stamina.

        A man who is carrying extra weight can often become fatigued faster than a guy of the proper weight; that is never more obvious than in the bedroom.

        A guy might notice that as he puts on the pounds. He has more trouble breathing during heavy sensual activity; and he might need to stop an enjoyable session before he wants to, just because his body can’t quite keep up the pace.

         

        2) He might develop skin problems.

        When someone is obese, he might have “rolls” of skin that rub together.

        Those areas can lead to redness, rashes, and even infection if he’s not extremely careful about hygiene.

        In addition, skin problems are common among those who have underlying problems; such as uncontrolled diabetes, as they make certain infections more common.

         

        3) He might suffer from nerve damage.

        The nerves of the member – and the rest of the body, for that matter – are very delicate and ready to respond to the slightest touch or sensation.

        But for those with obesity, the excess weight can put too much pressure on the nerves, leading to a deadening of sensation or even some measure of pain.

        Those who have problems with blood flow as a result of the pressure might also suffer from loss of sensation.

         

        4) He might not be able to get it up.

        Everyone knows heart problems are the norm with obesity. But many men don’t think about the fact that a healthy heart is required for healthy manhood – specifically, that great blood flow is a must to get and maintain tumescence.

        Those who are too heavy might notice that their hardness is no longer as strong as it once was, or that they don’t last if they once did.

         

        5) He might seem to be “smaller” than he used to be.

        No, the member doesn’t get smaller, but it can certainly look like it has. Why? Because every man has a “fat pad” right above his manhood.

        When a guy is fit, he doesn’t notice this area at all. But as a guy gains weight, that fat pad becomes bigger, and eventually, it protrudes enough to make the member look smaller.

        This can affect what a partner thinks the first time she lays eyes on the equipment.

         

        6) He might get depressed.

        Self-esteem is vitally important for anyone, and a guy who is suffering in that area might suffer in other ways, too.

        When a man starts to feel trapped by the extra weight and feels as though losing it is hopeless or will take far too long. He might become depressed, anxious, withdrawn, and a whole host of other things that don’t bode well for his relationships.

        When a man is dealing with too much weight, keeping healthy manhood might be enough incentive to help a man start losing it.

        To avoid male organ problems in the meantime, a guy should reach for a great member health crème(Health professionals recommend Man 1 Man Oil, which is clinically proven mild and safe for skin) every day.

        The right crème will contain amino acids like L-carnitine and L-arginine, which work together to help improve blood flow as well as protect nerve function.

        Visit www.menshealthfirst.com for more information about treating common male organ health problems; including soreness, redness, and loss of male organ sensation. John Dugan is a professional writer who specializes in men’s health issues and is an ongoing contributing writer to numerous online web sites.